Genome flux and stasis in a five millennium transect of European prehistory

Authors/others:Gamba, Cristina (University College Dublin); Jones, Eppie R. (University of Dublin); Teasdale, Matthew D. (University of Dublin); McLaughlin, Russell L (University of Dublin); Gonzalez-Fortes, Gloria (Universität Potsdam); Mattiangeli, Valeria (University of Dublin); Domboróczki, László (Dobó István Castle Museum, Vár utca 1, H-3300 Eger, Hungary); Kővári, Ivett (JPAC-Central Identification Laboratory, 310 Worchester Avenue, Building. 45 Joint Base Pearl Harbor-Hickam, Honalulu, Hawaii 96853-5530, USA); Pap, Ildikó (Hungarian Natural History Museum); Anders, Alexandra (Eötvös Loránd University Budapest); Whittle, Alasdair (Cardiff University); Dani, János (Déri Museum, Déri tér 1, H-4026 Debrecen, Hungary); Raczky, Pál (Eötvös Loránd University Budapest); Higham, Thomas F G (University of Oxford); Hofreiter, Michael (Universität Potsdam); Bradley, Daniel G. (University of Dublin); Pinhasi, Ron (University College Dublin)
Abstract:The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (~22 × ) and seven to ~1 × coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.
Date of publication:2014
Journal title:Nature Communications
Peer reviewed:true
Digital Object Identifier (DOI):
Publication Type:Article